Table 2.
Correlation between differentially methylated regions in old intrauterine growth restriction islets and proximal gene expression at age 2 weeks
| Gene name | Symbol | DMRs | RNA-seq | |
|---|---|---|---|---|
| CpGs location | ΔMethylationa,b, % | LogFCa,b | ||
| SH3 domain binding kinase 1 | Sbk1 | Intergenic | –34.6 | –1.27 |
| Phenylalanine hydroxylase | Pah | Intron 3 | –12.6 | –1.93 |
| Chymotrypsin-like elastase 1 | Cela1 | Intron 4-6 | –12.8 | –3.02 |
| Calmodulin-regulated spectrin-associated protein family, member 3 | Camsap3 | Intron 1 | –23.1 | –1.07 |
| Glycoprotein 2 | Gp2 | Intergenic | –35.1 | –2.63 |
| Solute carrier family 4 member 8 | Slc4a8 | Intergenic | –22.3 | –1.34 |
| Phosphodiesterase 8B | Pde8b | Intron 4-5 | –24.2 | –1.39 |
| LBH regulator of WNT signaling pathway | Lbh | Intergenic | –18.0 | –1.09 |
| Cysteine and serine-rich nuclear protein 1 | Csrnp1 | Exon 4 | –11.2 | 1.13 |
| Histocompatibility minor 13 | Hm13 | Intergenic | –16.5 | –0.89 |
| Tubulin tyrosine ligase-like 10 | Ttll10 | Intron 3-5 | –20.5 | –1.45 |
| Connector enhancer of kinase suppressor of Ras 1 | Cnksr1 | Intergenic | –23.0 | –0.91 |
| Phosphofructokinase, platelet | Pfkp | Intergenic | –21.4 | 0.69 |
| Gasdermin C | Gsdmc | Intergenic | –29.3 | 3.77 |
| Carboxypeptidase A4 | Cpa4 | Intergenic | –28.3 | –3.56 |
| RNA binding protein, mRNA processing factor | Rbpms | Promoter | –24.8 | 0.63 |
| Echinoderm microtubule associated protein-like 1 | Eml1 | Intron 2 | –31.1 | 0.66 |
| Echinoderm microtubule associated protein-like 1 | Eml1 | Intron 4 | –13.5 | 0.66 |
| Calcium/calmodulin-dependent protein kinase 2 | Camkk2 | Intron 1 | –14.0 | –0.71 |
| NFKB inhibitor α | Nfkbia | Intergenic | –26.1 | 0.90 |
| Olfactomedin 1 | Olfm1 | Intergenic | –12.7 | 1.17 |
| Erythrocyte membrane protein band 4.1-like 4A | Epb41l4a | Intergenic | –24.0 | –0.58 |
| Annexin A1 | Anxa1 | Intergenic | –36.2 | 0.87 |
| 5-Hydroxytryptamine receptor 2A | Htr2a | Intergenic | –21.8 | 1.01 |
| Collagen type V α 3 chain | Col5a3 | Exon 36-41 | –21.4 | 0.84 |
| Docking protein 5 | Dok5 | Intron 1 | –24.2 | 1.67 |
| Calmin | Clmn | Intergenic | –20.7 | –0.81 |
| HtrA serine peptidase 1 | Htra1 | Intron 3-5 | –18.9 | 0.66 |
| Intersectin 1 | Itsn1 | Intron and exon 30 | –14.8 | 0.54 |
| BTB domain and CNC homolog 1 | Bach1 | Intergenic | –35.3 | –0.59 |
| Ventricular zone-expressed PH domain-containing 1 | Veph1 | Intergenic | –24.8 | –1.34 |
Abbreviations: DMR, differentially methylated region; mRNA, messenger RNA; RNA-seq, RNA sequencing.
a ΔMethylation values are means from DNA methylome, and LogFC (fold change) values are means from transcriptome.
b Q values less than.05 for both DMR ΔMethylation and RNA-seq LogFC.