Table 2.
Hazard ratio (HR) estimates of breast-cancer risk for weight change from age 20 years to baseline with follow-up on weight as an update in women with breast cancer overall (ca = 6352), pre/perimenopausal (ca = 1461) and postmenopausal breast cancer (ca = 4891) at diagnosis
| Overall (ca = 6352) |
Premenopausal (ca = 1461)c |
Postmenopausal (ca = 4891)d |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1a |
Model 2b |
Model 1 |
Model 2 |
Model 1 |
Model 2 |
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| Weight change (kg) | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | ||||||
| <–2.5 | 391 | 0.93 | 0.82 | 1.06 | 391 | 0.95 | 0.83 | 1.09 | 135 | 0.99 | 0.78 | 1.24 | 135 | 1.03 | 0.81 | 1.32 | 256 | 0.96 | 0.80 | 1.15 | 256 | 0.95 | 0.78 | 1.15 |
| ±2.5 | 731 | 1 | Ref. | 731 | 1 | Ref. | 264 | 1 | Ref. | 264 | 1 | Ref. | 467 | 1 | Ref. | 467 | 1 | Ref. | ||||||
| 2.51–5 | 629 | 1.10 | 0.99 | 1.22 | 629 | 1.09 | 0.98 | 1.22 | 191 | 0.98 | 0.81 | 1.18 | 191 | 0.98 | 0.81 | 1.19 | 438 | 1.18 | 1.01 | 1.37 | 438 | 1.17 | 1.01 | 1.37 |
| 5.1–10 | 1421 | 1.14 | 1.04 | 1.25 | 1421 | 1.13 | 1.03 | 1.24 | 354 | 1.02 | 0.86 | 1.20 | 354 | 1.03 | 0.87 | 1.22 | 1067 | 1.20 | 1.05 | 1.37 | 1067 | 1.17 | 1.02 | 1.34 |
| 10+ | 3180 | 1.24 | 1.14 | 1.34 | 3180 | 1.23 | 1.13 | 1.34 | 517 | 0.97 | 0.83 | 1.13 | 517 | 0.99 | 0.84 | 1.16 | 2663 | 1.37 | 1.22 | 1.55 | 2663 | 1.36 | 1.20 | 1.53 |
| P-trend | <0.0001 | <0.0001 | 0.79 | 0.84 | <0.0001 | <0.0001 | ||||||||||||||||||
Stratified by centre and age at recruitment (categorical 5-year interval).
Stratified by centre and age at recruitment (categorical 5-year interval) and adjusted for weight at age 20 years (continuous), height (continuous), age at menarche (<12, 12, 13, 14, ≥15 years, missing), number of pregnancies (nulliparous, 1, 2, 3, 4, 5, >5, missing), age at first pregnancy (<20, 20–30, >30 years, nulliparous, missing), education (none, primary school, technical/professional school, secondary school, university degree, missing), alcohol consumption (non-drinkers, ≤1, >1 glass/week, missing), smoking status (never, former, current smoker, missing), physical activity (minimum, moderate, intense, missing), use of oral contraceptives (never, ever users, missing) and menopausal hormone therapy (never, ever users, missing).
Pre/perimenopausal at cohort entry and premenopausal at diagnosis.
Pre/perimenopausal or postmenopausal at cohort entry and postmenopausal at diagnosis.
95% CI, 95% confidence interval.