Table 3.
Cross-classification of weight change and body mass index (BMI) at age 20 years in overall (n = 150 257), pre/peri (n = 78 506) and postmenopausal women (71 751)
| Overall (n = 150 257/ca = 6352) |
Pre-/perimenopausal (n = 78 506/ca = 1461) |
Postmenopausal (n = 71 751/ca = 4891) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI20 <25 kg/m2 ca = 3855 |
BMI20 ≥25 kg/m2 ca = 2497d |
BMI20 ≥25 kg/m2e |
BMI20 <25 kg/m2 ca = 523 |
BMI20 ≥25 kg/m2 ca = 938d |
BMI20 ≥25 kg/m2e |
BMI20 <25 kg/m2 ca = 3332 |
BMI20 ≥25 kg/m2 ca = 1559d |
BMI20 ≥25 kg/m2e |
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| Weight change (kg) | Cases (n) | HRa | 95% CI | Cases (n) | HRb | 95% CI | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | HR | 95% CI | |||||||||
| <–2.5 | 126 | 0.85 | 0.68 | 1.05 | 265 | 1.02 | 0.86 | 1.21 | 1.05 | 0.89 | 1.24 | 29 | 1.09 | 0.65 | 1.84 | 106 | 0.75 | 0.51 | 1.10 | 1.04 | 0.77 | 1.41 | 97 | 0.93 | 0.72 | 1.21 | 159 | 1.03 | 0.79 | 1.35 | 0.96 | 0.72 | 1.27 |
| ±2.5 | 351 | 1.00 | Ref. | 380 | 0.97 | 0.83 | 1.13 | 1.00 | Ref. | 81 | 1.00 | Ref. | 183 | 0.72 | 0.52 | 1.00 | 1.00 | Ref | 270 | 1.00 | Ref | 197 | 1.08 | 0.86 | 1.35 | 1.00 | Ref | ||||||
| 2.51–5 | 340 | 1.04 | 0.89 | 1.22 | 289 | 0.97 | 0.83 | 1.15 | 1.00 | 0.86 | 1.17 | 65 | 0.93 | 0.63 | 1.39 | 126 | 0.73 | 0.53 | 1.03 | 1.02 | 0.80 | 1.30 | 275 | 1.17 | 0.96 | 1.42 | 163 | 1.25 | 0.99 | 1.58 | 1.16 | 0.90 | 1.49 |
| 5.1–10 | 865 | 1.12 | 0.99 | 1.28 | 556 | 1.01 | 0.88 | 1.16 | 1.04 | 0.91 | 1.19 | 119 | 0.74 | 0.52 | 1.06 | 235 | 0.85 | 0.63 | 1.16 | 1.18 | 0.96 | 1.45 | 746 | 1.24 | 1.05 | 1.47 | 321 | 1.08 | 0.88 | 1.33 | 1.00 | 0.80 | 1.26 |
| 10+ | 2173 | 1.26 | 1.12 | 1.42 | 1007 | 1.14 | 1.00 | 1.30 | 1.18 | 1.04 | 1.33 | 229 | 0.95 | 0.69 | 1.30 | 288 | 0.70 | 0.51 | 0.94 | 0.96 | 0.79 | 1.18 | 1944 | 1.42 | 1.22 | 1.65 | 719 | 1.30 | 1.10 | 1.55 | 1.21 | 0.99 | 1.47 |
| P-intc | 0.48 | 0.05 | 0.33 | ||||||||||||||||||||||||||||||
HR, hazard ratio.
Stratified by centre and age at recruitment (categorical 5-year interval) and adjusted for weight at age 20 years, height, age at menarche, number of pregnancies, age at first pregnancy, education, alcohol consumption, smoking status, physical activity, use of oral contraceptives and menopausal hormone therapy.
P-int = P for interaction using likelihood-ratio test comparing cross-classification model (BMI20*weight change) with a model including BMI20 and weight change as separate variables.
This column has BMI20 <25 and ±2.5 kg as reference group.
This column has BMI ≥25 and ±2.5 kg as reference group.
95% CI, 95% confidence interval; HR, hazard ratio.