Table 6.
Hazard ratio (HR) estimates of weight change from age 20 years to baseline and risk of breast cancer overall by hormone-receptor status (n = 150 257)
| ER+b ca = 2190 |
ER–c ca = 492 |
ER+PR+d ca = 1062 |
ER–PR–e ca = 330 |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Weight change (kg) | Cases (n) | HRa | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | Cases (n) | HR | 95% CI | ||||
| <–2.5 | 103 | 0.85 | 0.66 | 1.09 | 29 | 0.93 | 0.56 | 1.54 | 44 | 0.82 | 0.54 | 1.25 | 19 | 0.95 | 0.49 | 1.83 |
| ±2.5 | 219 | 1.00 | Ref | 49 | 1.00 | Ref | 100 | 1.00 | Ref | 30 | 1.00 | Ref | ||||
| 2.51–5 | 205 | 1.17 | 0.97 | 1.42 | 47 | 1.07 | 0.70 | 1.62 | 99 | 1.69 | 1.27 | 2.24 | 33 | 1.13 | 0.66 | 1.94 |
| 5.1–10 | 454 | 1.01 | 0.85 | 1.20 | 116 | 1.32 | 0.93 | 1.87 | 234 | 1.29 | 0.99 | 1.67 | 79 | 1.54 | 0.99 | 2.40 |
| 10+ | 1209 | 1.24 | 1.06 | 1.44 | 251 | 1.26 | 0.91 | 1.73 | 585 | 1.46 | 1.15 | 1.85 | 169 | 1.44 | 0.95 | 2.18 |
| P-trend | <0.0001 | 0.06 | 0.002 | 0.03 | ||||||||||||
a
Stratified by centre and age at recruitment (categorical 5-year interval) and adjusted for weight at age 20 years, height, age at menarche, age at first pregnancy, education, alcohol consumption, smoking status, physical activity, use of oral contraceptives and hormone replacement therapy.
b
ER+ = estrogen-receptor-positive breast cancer.
c
ER– = estrogen-receptor-negative breast cancer.
d
ER+PR+ = estrogen-and-progesterone-receptor-positive breast cancer.
e
ER–PR– = estrogen-and-progesterone-receptor-negative breast cancer.
95% CI, 95% confidence interval.