Table 2.
Estimated rates of incidence, severe illness, and mortality in mainland China by different stages of vaccine launch, 2013–19.
| Before the EV-A71 Vaccines Launch |
2016 | After the EV-A71 Vaccines Launch |
|||||
|---|---|---|---|---|---|---|---|
| 2013 | 2014 | 2015 | 2017 | 2018 | 2019 | ||
| Incidence rates (95% CI) | |||||||
| <12 months | 24881·9 (24801·5,24962·4) | 28865·4 (28780·6,28950·3) | 26028·0 (25947·9,26108·2) | 19474·2 (19405·5,19542·9) | 19096·7 (19029·2,19164·3) | 17944·7 (17879·1,18010·2) | 13910·7 (13852·9,13968·5) |
| 12–23 months | 35810·7 (35722·0,35899·3) | 48395·8 (48295·1,48496·5) | 36279·9 (36192·7,36367·1) | 41494·0 (41400·9,41587·1) | 32842·2 (32759·6,32924·9) | 42409·5 (42316·0,42502·9) | 32399·4 (32317·3,32481·5) |
| 24–35 months | 22594·1 (22521·4,22666·8) | 32585·2 (32500·2,32670·2) | 22957·3 (22886·2,23028·5) | 29235·3 (29155·1,29315·4) | 21353·3 (21285·0,21421·6) | 24417·5 (24344·6,24490·3) | 23278·5 (23207·3,23349·7) |
| 36–59 months | 12401·4 (12361·6,12441·1) | 23571·6 (23517·0,23626·1) | 13866·6 (13824·8,13908·5) | 22199·5 (22146·7,22252·3) | 15904·3 (15859·7,15948·8) | 20199·1 (20149·0,20249·2) | 17258·2 (17211·8,17304·5) |
| 5–9 years | 1360·8 (1352·8,1368·9) | 2756·4 (2745·0,2767·8) | 1578·6 (1570·0,1587·2) | 2630·9 (2619·9,2642) | 1968·4 (1958·8,1977·9) | 2851·2 (2839·7,2862·7) | 2733·4 (2722·1,2744·6) |
| 10–14 years | 212·0 (208·5,215·5) | 321·2 (316·8,325·5) | 210·7 (207·1,214·2) | 299·5 (295·3,303·8) | 250·1 (246·3,253·9) | 384·3 (379·6,389·1) | 353·2 (348·7,357·8) |
| ≥15 years | 8·9 (8·8,9·1) | 10·8 (10·6,11·0) | 9·9 (9·7,10·1) | 10·1 (9·9,10·2) | 10·9 (10·7,11·1) | 16·3 (16·0,16·5) | 14·5 (14·2,14·7) |
| Severe illness rates (95% CI)* | |||||||
| <12 months | 140·3 (134·2,146·4) | 302·3 (293·5,311·1) | 150·9 (144·7,157·1) | 146·5 (140·5,152·6) | 119·1 (113·7,124·5) | 48·6 (45·2,52·1) | 24·1 (21·7,26·5) |
| 12–23 months | 248·9 (241·4,256·4) | 577·9 (566·6,589·2) | 219·5 (212·5,226·4) | 345·8 (337·1,354·4) | 231·2 (224·1,238·2) | 118·5 (113·5,123·6) | 58·3 (54·7,61·8) |
| 24–35 months | 132·4 (126·8,138·1) | 300·4 (292·1,308·7) | 109·7 (104·8,114·7) | 192·9 (186·3,199·5) | 120·1 (114·9,125·3) | 45·3 (42·2,48·5) | 27·5 (25.0,29·9) |
| 36–59 months | 53·1 (50·5,55·7) | 138·0 (133·8,142·3) | 49·0 (46·5,51·5) | 86·1 (82·8,89·5) | 62·4 (59·6,65·2) | 24·9 (23·1,26·6) | 11·5 (10·3,12·7) |
| 5–9 years | 3·9 (3·4,4·3) | 10·5 (9·8,11·2) | 3·6 (3·2,4·0) | 6·3 (5·7,6·8) | 5·6 (5·1,6·1) | 2·8 (2·4,3·2) | 1·0 (0·8,1·2) |
| 10–14 years | 0·3 (0·2,0·5) | 0·7 (0·5,1·0) | 0·3 (0·2,0·4) | 0·5 (0·3,0·6) | 0·4 (0·3,0·6) | 0·3 (0·2,0·5) | 0·1 (0·0,0·2) |
| ≥15 years # | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) | 0·0 (0·0,0·0) |
| Mortality rates (95% CI)* | |||||||
| <12 months | 4·0 (3·0,5·1) | 8·3 (6·8, 9·7) | 2·1 (1·4, 2·8) | 2·7 (1·9, 3·5) | 1·8 (1·2, 2·5) | 0·4 (0·2, 0·9) | 0·4 (0·1, 0·8) |
| 12–23 months | 6·5 (5·2,7·7) | 11·1 (9·6, 12·7) | 2·8 (2·0, 3·6) | 4·5 (3·5, 5·5) | 1·6 (1·0, 2·1) | 1·1 (0·6, 1·6) | 0·3 (0·1, 0·7) |
| 24–35 months | 3·6 (2·6, 4·5) | 5·8 (4·7, 7·0) | 1·6 (1·0, 2·2) | 2·3 (1·6, 3·0) | 1·0 (0·6, 1·6) | 0·2 (0·1, 0·6) | 0·2 (0·1, 0·6) |
| 36–59 months | 0·7 (0·4, 1·0) | 2·6 (2·0, 3·2) | 0·6 (0·3, 0·9) | 1·0 (0·7, 1·4) | 0·5 (0·3, 0·9) | 0·1 (0·0, 0·3) | 0·1 (0·0, 0·2) |
| 5–9 years # | 0·0 (0·0, 0·1) | 0·1 (0·0, 0·2) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·1 (0·0, 0·1) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·1) |
| 10–14 years # | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) | 0·0 (0·0, 0·1) |
| ≥15 years # | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) | 0·0 (0·0, 0·0) |
⁎
per 1 million.
#
More detailed information is provided in the supplementary file in Table A4.