Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 18;43(1):64–74. doi: 10.24272/j.issn.2095-8137.2021.281

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Defective retinal angiogenesis and pathological NV in Tg-Twist1^iEC+ mice at P6

A: Tg-Twist1^iEC+ and control mice were intraperitoneally injected with tamoxifen at P2 to P4 and analyzed at P6. B–D: Isolectin B4 staining of retinal whole mounts showed delayed superficial vascular progression and increased vascular density in retinas of Tg-Twist1^iEC+ mice compared with littermate WT mice. Scale bar: 250 μm for B; 100 μm for C; E: Arrows indicate aneurysmal-like pathological NV in Tg-Twist1^iEC+ retinas. Scale bar: 50 μm. F: Red blood cells stained with Ter119 antibody show vessel leakage in Tg-Twist1^iEC+ retinas, indicated by arrows. ^**: P<0.01; ^***: P<0.001; two-tailed t-test. Scale bars: 50 μm.