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. 2022 Jan 10;116:258–267. doi: 10.1016/j.ijid.2022.01.008

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Figure 4: — Analysis of differentiated expressed proteins (DEPs) between different groups. A. Hierarchical clustering analysis of DEPs. A heatmap showing the top 11 DEPs. The red and the blue colors in the heatmap denote higher gene expression and lower gene expression, respectively. Target protein symbols for the top 11 DEPs are included; B. These dysregulated proteins are enriched in 2 pathways: complement and coagulation cascades pathways and platelet activation (both of which contain DEPs at a high frequency); C. The change in expression level (original value) of the 11 selected proteins with significance is indicated by the P value. COVID-19, NCP; COPD, chronic obstructive pulmonary disease.