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. 2022 Jan 10;342:241–279. doi: 10.1016/j.jconrel.2022.01.008

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Fig. 14 — Components and formulation of targeted NP-containing siRNA. (A) The delivery components are (i) a water-soluble, linear cyclodextrin-containing polymer (CDP), (ii) an adamantane (AD)-PEG conjugate (PEG MW of 5000) (AD-PEG), and (iii) the targeting component that is an adamantane conjugate of PEG (PEG MW of 5000) that has human transferrin (Tf) conjugated at the end opposite to the adamantane (Tf-PEG-AD). (B) The formulation contains two vials, one with siRNA and the other with the delivery components. When the two vials are mixed together, the targeted NPs form via self-assembly of the four components [213]. Reproduced with the permission from Ref. 213. Copyright © 2009 American Chemical Society.