Fig. 15.

Biomimetic vectors for RNAs delivery. Many kinds of cells can be used as a source for biomimetic vectors including RBC, white blood cell (WBC), platelet, mesenchymal stem cell (MSC), cancer cell, et al. cell membrane originated from these cells (a) can be directly used to coat RNA loaded nanoparticles to produce biomimetic nanoparticles inheriting donor cells' features. Or by transfecting plasmids into cells (b) to realize active RNA loading process with the help of endogenous mechanism of parent cells. Or by first isolating EVs and then loading RNA drugs (c) to construct RNA loaded EVs.