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. 2022 Jan 5;15:45–58. doi: 10.2147/DMSO.S342799

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© 2022 Powell et al.

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Gpr75 KO and WT mice exhibit comparable activity early in life as low body fat phenotype is developing. Individually housed Gpr75 KO (9 female, 9 male) and WT (9 female, 9 male) mice were studied for 27 days starting immediately after weaning onto HFD. Change (∆) in (A) body weight and (B) body fat during this 27-day interval. Mean 12-hour (C) dark cycle and (D) light cycle circadian locomotor activity levels in all mice over this 27-day period, based on data from 22 full 12-hour dark cycles and 19 full 12-hour light cycles. KO mice different from WT mice of the same age and sex, *P < 0.05, **P < 0.01.