Figure 6.

Decreased food intake by female and male Gpr75 KO mice early in life as low body fat phenotype is developing. Gpr75 KO mice (22 female, 22 male) and WT mice (19 female, 21 male) group housed by sex and genotype (2–3 mice/cage) were studied for 7 days starting immediately after weaning onto HFD. Change (∆) in (A) female body weight, (B) female body fat, (C) male body weight, and (D) male body fat over these 7 days. Daily food intake in grams (g) for female (E) and male (F) mice during the 5 intervals where food intake was measured, calculated as mean food intake/mouse for each cage of group-housed KO mice (16 cages, 8 female and 8 male) and WT mice (14 cages, 7 female and 7 male). KO mice different from WT mice, *P < 0.05, **P < 0.01.