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. 2022 Jan 5;15:45–58. doi: 10.2147/DMSO.S342799

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© 2022 Powell et al.

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Improved glucose homeostasis in adult Gpr75 KO mice. (A) Glucose excursions, and (B) 0-minute and 30-minute insulin levels, from OGTTs performed on HFD-fed female Gpr75 KO mice (n=28) and their WT littermates (n=20) at 24–30 weeks of age. (C) Glucose excursions, and (D) 0-minute and 30-minute insulin levels, from OGTTs performed on HFD-fed male Gpr75 KO mice (n=31) and their WT littermates (n=25) at 24–36 weeks of age. Log-transformed (E) HOMA and (F) composite insulin sensitivity index (ISI) values for all mice; higher ISI values indicate increased insulin sensitivity. KO mice different from WT mice, *P < 0.05, ***P < 0.001.