Table 1.
Mice | Age (Weeks) | Genotype | N | Body Weight (g) | Body Fat (g) | % Body Fat | LBM |
---|---|---|---|---|---|---|---|
All adult mice | 11–24 | WT | 103 | 100 ± 11 | 100 ± 27 | 100 ± 19 | 100 ± 8 |
KO | 118 | 83 ± 13*** | 51 ± 21***† | 61 ± 18*** | 96 ± 10***† | ||
Adult male mice fed chow | 14–24 | WT | 15 | 100 ± 9 | 100 ± 21 | 100 ± 17 | 100 ± 9 |
KO | 13 | 98 ± 13 | 68 ± 22*** | 69 ± 15*** | 105 ± 9 | ||
Adult female mice fed chow | 14–24 | WT | 16 | 100 ± 10 | 100 ± 25 | 100 ± 19 | 100 ± 8 |
KO | 20 | 89 ± 11** | 66 ± 21*** | 74 ± 17*** | 95 ± 10 | ||
Adult male mice fed HFD | 11–24 | WT | 41 | 100 ± 12 | 100 ± 30 | 100 ± 21 | 100 ± 7 |
KO | 51 | 79 ± 10*** | 46 ± 18***† | 58 ± 18*** | 93 ± 9*** | ||
Adult female mice fed HFD | 15–24 | WT | 31 | 100 ± 12 | 100 ± 29 | 100 ± 18 | 100 ± 7 |
KO | 34 | 82 ± 12*** | 47 ± 19***† | 56 ± 17*** | 99 ± 9 | ||
All mice at weaning | 3 | WT | 79 | 100 ± 17 | 100 ± 25 | 100 ± 10 | 100 ± 16 |
KO | 81 | 97 ± 12 | 92 ± 18* | 95 ± 9** | 98 ± 12 | ||
Male mice at weaning | 3 | WT | 40 | 100 ± 23 | 100 ± 28 | 100 ± 9 | 100 ± 22 |
KO | 43 | 96 ± 16 | 92 ± 20 | 97 ± 10 | 96 ± 15 | ||
Female mice at weaning | 3 | WT | 39 | 100 ± 17 | 100 ± 28 | 100 ± 12 | 100 ± 16 |
KO | 38 | 97 ± 14 | 90 ± 19 | 94 ± 9 | 99 ± 14 |
Notes: KO mice different from WT mice, *P < 0.05; **P < 0.01; ***P < 0.001; †Statistical analysis by Mann–Whitney test.
Abbreviations: N, number of mice; g, grams; LBM, lean body mass; WT, wild type; KO, knockout; HFD, high fat diet.