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. 2022 Jan 10;23:15. doi: 10.1186/s13059-021-02589-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Meta-analysis confirms ACE2 upregulation in all major types of cardiomyopathy. A The ACE2 expression in normal hearts and hearts with DCM. Data are from five RNA-seq datasets and one microarray dataset. The overall p value is calculated using a mixed model, with the dataset as the random effect and DCM as the fixed effect. B–E The ACE2 expression in normal hearts and hearts with HCM, RCM, LVNC, and ARVC. p values in B–E are calculated using t-tests