Phylogenomics of SARS-CoV-2 variants during the pre-vaccination stage in Mexico. (a) The Mexstrain phylogenomic tree showing VOI/VOC identified during the pre-vaccination stage. 20A/484K refers to the San Luis Potosi samples, belonging to lineages B.1 and B.1.319. (b) Geographical distribution of VOI/VOC in Mexico. (c) 20B/P.4 or 20B/B.1.1.28.4 evolving in Jalisco, Mexico, from P.2. ORF1a and spike protein amino acid mutations (ORF1a: V1071A, P1810L, S3149F; S: R190M) are indicated with green stars.