Table 1.
List of resistance loci screened in the study genomes
|
Phenotypic resistance to |
Gene |
Product |
M. abscessus subsp. abscessus ATCC 19977 locus tag |
|---|---|---|---|
|
Inducible macrolide resistance |
erm(41) |
23S rRNA methyltransferase |
MAB_2297 |
|
Constitutive macrolide resistance |
rrl |
23S ribosomal RNA |
MAB_r5052 |
|
Aminoglycoside |
rpsL |
30S ribosomal protein S12 |
MAB_3851c |
|
Aminoglycoside |
rrs |
16S ribosomal RNA |
MAB_r5051 |
|
Amikacin |
eis1 |
Gcn5-related N-acetyltransferase |
MAB_4124 |
|
Amikacin |
eis2 |
Gcn5-related N-acetyltransferase |
MAB_4532c |
|
Clofazimine and bedaquiline |
MAB_2299c |
Transcriptional regulatory protein |
MAB_2299c |
|
Clofazimine and bedaquiline |
MmpS-MmpL |
Membrane protein |
MAB_2300 – MAB_2301 |
|
Clofazimine and bedaquiline |
MmpS-MmpL |
Membrane protein |
MAB_1135c – MAB_1134c |
|
Tetracycline |
tetX |
FAD-binding monooxygenase |
MAB_1496c |
|
Tetracycline |
tetR |
TetR regulatory protein |
MAB_1497c |
|
Tigecycline |
whiB7 |
Transcriptional regulator |
MAB_3508c |
|
Rifampicin |
MAB_0591 |
Rifampin adp-ribosyl transferase |
MAB_0591 |
|
Multi-drug |
MAB_2780c |
Transporter |
MAB_2780c |
|
Multi-drug |
MAB_2958 |
Putative transmembrane-transport protein |
MAB_2958 |
|
Multi-drug |
MAB_1935 |
Putative drug resistance transporter |
MAB_1935 |