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. 2022 Jan 10;11(1):e1367. doi: 10.1002/cti2.1367

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© 2022 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Mucosal‐associated invariant T (MAIT) cells are decreased in the circulation of melanoma patients. (a) Example flow cytometric gating strategy to identify MAIT cell subsets in peripheral blood. Comparisons of MAIT cell subsets as a fraction of CD45⁺ cells (b), total T cells (c), parent T‐cell population (d) and of MAIT (e) in healthy donors (HD, n = 11) and treatment naïve (TN, n = 33) melanoma patients. (f) Comparisons of the frequency of PMA/ionomycin‐stimulated polyfunctional (TNFα⁺IFNγ⁺) cells as a percentage of the described population [(HD: n = 11), (TN: n = 15)]. Double negative (DN), *P < 0.05.