| 1.1 Health‐related quality of life (HRQoL): adjusted SGRQ total score (primary analysis) |
14 |
2778 |
Mean Difference (IV, Random, 95% CI) |
‐2.86 [‐4.87, ‐0.85] |
| 1.2 Health‐related quality of life (HRQoL): adjusted SGRQ total score (secondary analysis) |
14 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.2.1 HRQoL: adjusted SGRQ total short term follow‐up (≤ 6 months) |
7 |
1461 |
Mean Difference (IV, Random, 95% CI) |
‐2.36 [‐4.92, 0.20] |
| 1.2.2 HRQoL: adjusted SGRQ total medium term follow‐up (>6‐≤12 months) |
13 |
2651 |
Mean Difference (IV, Random, 95% CI) |
‐2.65 [‐4.78, ‐0.52] |
| 1.3 Health‐related quality of life (HRQoL): CRQ domain scores (primary analysis) |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.3.1 HRQoL: CRQ ‐ dyspnoea |
5 |
738 |
Mean Difference (IV, Random, 95% CI) |
0.13 [‐0.10, 0.35] |
| 1.3.2 HRQoL: CRQ ‐ mastery |
5 |
738 |
Mean Difference (IV, Random, 95% CI) |
0.12 [‐0.09, 0.33] |
| 1.3.3 HRQoL: CRQ ‐ fatigue |
5 |
738 |
Mean Difference (IV, Random, 95% CI) |
0.23 [‐0.01, 0.47] |
| 1.3.4 HRQoL: CRQ ‐ emotional function |
5 |
738 |
Mean Difference (IV, Random, 95% CI) |
0.20 [‐0.06, 0.46] |
| 1.4 Health‐related quality of life (HRQoL): CRQ domain scores (secondary analyses) |
4 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.4.1 HRQoL: CRQ ‐ dyspnoea (≤ 6 months) |
3 |
386 |
Mean Difference (IV, Random, 95% CI) |
0.23 [‐0.15, 0.61] |
| 1.4.2 HRQoL: CRQ ‐ mastery (≤6 months) |
3 |
386 |
Mean Difference (IV, Random, 95% CI) |
0.12 [‐0.33, 0.57] |
| 1.4.3 HRQoL: CRQ ‐ fatigue (≤6 months) |
3 |
386 |
Mean Difference (IV, Random, 95% CI) |
0.11 [‐0.55, 0.77] |
| 1.4.4 HRQoL: CRQ ‐ emotional function (≤6 months) |
3 |
386 |
Mean Difference (IV, Random, 95% CI) |
0.22 [‐0.37, 0.82] |
| 1.4.5 HRQoL: CRQ ‐ dyspnoea (>6‐≤12 months) |
3 |
557 |
Mean Difference (IV, Random, 95% CI) |
0.13 [‐0.09, 0.34] |
| 1.4.6 HRQoL: CRQ ‐ mastery (>6‐≤12 months) |
3 |
557 |
Mean Difference (IV, Random, 95% CI) |
0.17 [‐0.07, 0.41] |
| 1.4.7 HRQoL: CRQ ‐ fatigue (>6‐≤12 months) |
3 |
557 |
Mean Difference (IV, Random, 95% CI) |
0.22 [‐0.15, 0.59] |
| 1.4.8 HRQoL: CRQ ‐ emotional function (>6‐≤12 months) |
3 |
557 |
Mean Difference (IV, Random, 95% CI) |
0.12 [‐0.27, 0.51] |
| 1.5 Healthcare utilisation: respiratory‐related hospital admissions (number of participants with at least one admission) (primary analysis) |
15 |
3263 |
Odds Ratio (M‐H, Random, 95% CI) |
0.75 [0.57, 0.98] |
| 1.6 Healthcare utilisation: respiratory‐related hospital admissions (number of participants with at least one admission) (secondary analyses) |
15 |
|
Odds Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.6.1 Healthcare utilisation: respiratory‐related hospital admissions ≤ 6 months (number of participants with at least one admission) |
4 |
437 |
Odds Ratio (M‐H, Random, 95% CI) |
0.84 [0.45, 1.55] |
| 1.6.2 Healthcare utilisation: respiratory‐related hospital admissions > 6 to ≤ 12 months (number of participants with at least one admission) |
11 |
2826 |
Odds Ratio (M‐H, Random, 95% CI) |
0.74 [0.53, 1.03] |
| 1.7 Healthcare utilisation: respiratory‐related hospital admissions (mean number per participant) (primary analysis) |
7 |
1572 |
Mean Difference (IV, Random, 95% CI) |
‐0.29 [‐0.60, 0.01] |
| 1.8 Healthcare utilisation: respiratory‐related hospital admissions (mean number per participant) (secondary analyses) |
7 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.8.1 Healthcare utilisation: respiratory‐related hospital admissions ≤ 6 months (mean number per participant) |
3 |
709 |
Mean Difference (IV, Random, 95% CI) |
‐0.01 [‐0.04, 0.02] |
| 1.8.2 Healthcare utilisation: respiratory‐related hospital admissions >6 ‐ ≤12 months (mean number per participant) |
6 |
1548 |
Mean Difference (IV, Random, 95% CI) |
‐0.33 [‐0.68, 0.01] |
| 1.9 Mortality: respiratory‐related mortality (primary analysis) |
8 |
1572 |
Risk Difference (M‐H, Random, 95% CI) |
0.01 [‐0.02, 0.04] |
| 1.10 Mortality: respiratory‐related mortality (secondary analyses) |
7 |
|
Risk Difference (M‐H, Random, 95% CI) |
Subtotals only |
| 1.10.1 Respiratory‐related ≤ 6 months mortality |
4 |
309 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.05, 0.03] |
| 1.10.2 Respiratory‐related > 6 to ≤ 12 months mortality |
6 |
1322 |
Risk Difference (M‐H, Random, 95% CI) |
0.01 [‐0.01, 0.03] |
| 1.11 Mortality: all‐cause mortality (primary analysis) |
24 |
5719 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.03, 0.01] |
| 1.12 Mortality: all‐cause mortality (secondary analyses) |
24 |
|
Risk Difference (M‐H, Random, 95% CI) |
Subtotals only |
| 1.12.1 All‐cause ≤ 6 months mortality |
9 |
1678 |
Risk Difference (M‐H, Random, 95% CI) |
0.00 [‐0.01, 0.01] |
| 1.12.2 All‐cause > 6 to ≤ 12 months mortality |
21 |
5240 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.01 [‐0.03, 0.01] |
