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. 2021 Jun 4;85(1):1–10. doi: 10.4046/trd.2021.0022

Table 1.

Strength of recommendations

Criterion Definition Suggestion
Class I Benefit >> risk Procedure/treatment should be performed.
Procedure or treatment is beneficial, useful, and effective. Is recommended/is indicated
Class IIa Benefit>risk It is reasonable to perform this procedure/treatment.
Evidence or opinion is useful or efficacious. Should be considered
Class IIb Benefit≥risk Procedure/treatment may be considered.
Additional studies should be conducted to address broad objectives because usefulness/efficacy is well established to a lesser extent.
Class III Benefit≤risk Procedure/treatment should not be performed.
Procedure or treatment is not useful or is potentially harmful Is not recommended