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. 2021 Dec 17;26(2):548–562. doi: 10.1111/jcmm.17121

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Differential correlation analysis of circulating miRNAs. Differential correlation analysis was conducted with 118 miRNAs to identify miRNA pairs that show significantly different correlations at 14°C compared to RT. (A) Hierarchical clustering of correlogram based on differences in correlation values at 14°C and RT. Each cell is the difference in correlation of a miRNA pair and is coloured according to the colour key shown at the bottom. (B) Examples of differential correlations among miRNA pairs. Correlations at 14°C and RT are shown side by side for miRNA pairs listed on the x‐ and y‐axis (in log 2 expression units)