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. 2021 Dec 10;26(2):410–421. doi: 10.1111/jcmm.17093

FIGURE 7.

FIGURE 7

IGF2BP3 mRNA and protein levels in nasopharyngeal carcinoma and the relationship between IGF2BP3 expression and patient prognosis. (A) qRT‐PCR analysis was performed to determine IGF2BP3 mRNA levels in 35 fresh nasopharyngeal carcinoma and 12 adjacent normal tissues. (B) Immunohistochemistry (IHC) staining was performed to measure IGF2BP3 protein levels in 112 paraffin‐embedded nasopharyngeal carcinoma and 32 paraffin‐embedded adjacent normal tissues. (C) IGF2BP3 protein levels were positively correlated with distant metastasis after initial treatment. (D, E) High IGF2BP3 expression was associated with poor overall survival and distant metastasis‐free survival. (F) The nomogram of IGF2BP3 and other clinicopathological characteristics in predicting distant metastasis. Expression differences between NPC and normal tissue were assessed using Wilcoxon rank‐sum tests. Survival analyses were performed by plotting Kaplan‐Meier survival curves, and a log‐rank test was used to evaluate the difference. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)