Table 2.
Clinicopathologic characteristics according to PTTG1 expression
| Variable | Negative or low PTTG1 (n = 62) | High PTTG1 (n = 25) | p-value |
|---|---|---|---|
| Age (yr) | .656 | ||
| Median (range) | 53 (31–83) | 55 (16–83) | |
| Sex | .183 | ||
| Male | 37 (59.7) | 11 (44.0) | |
| Female | 25 (40.3) | 14 (56.0) | |
| Invasiveness status | |||
| Suprasellar extension | .033a | ||
| Present | 52 (83.9) | 25 (100) | |
| Absent | 10 (16.1) | 0 | |
| Cavernous sinus invasion | .027a | ||
| Present | 19 (30.6) | 14 (56.0) | |
| Absent | 43 (69.4) | 11 (44.0) | |
| Tumor size (mm)b | .612 | ||
| Mean ± SD | 29.0 ± 13.5 | 26.5 ± 9.2 | |
| Recurrence | |||
| Present | 13 (21.0) | 3 (12.0) | .329 |
| Absent | 49 (79.0) | 22 (88.0) | |
| Present (N-PRT) | 11 (28.9) | 0 (0.0) | .103 |
| Absent (N-PRT) | 27 (71.1) | 14 (100.0) | |
| E-cadherin | .183 | ||
| Positive (score 1–3) | 25 (40.3) | 14 (56.0) | |
| Negative (score 0) | 37 (59.7) | 11 (44.0) | |
| Ki-67 index (%) | .389 | ||
| Mean ± SD | 1.3 ± 1.1 | 1.8 ± 2.5 | |
Values are presented as number (%) unless otherwise indicated.
PTTG1, pituitary tumor transforming gene 1; SD, standard deviation; N-PRT, no post-operative radiotherapy.
a
Statistically significant (p < .05);
b
Unknown tumor size in two cases with low PTTG1 expression.