Table 3.
Clinicopathologic characteristics according to tumor invasiveness group
| Variable | Tumor invasion group | p-value | ||
|---|---|---|---|---|
|
| ||||
| I (n = 7) | II (n = 50) | III (n = 30) | ||
| Age (yr) | .605 | |||
| Median (range) | 50 (42–71) | 55 (16–83) | 54.5 (31–83) | |
| Sex (%) | .790 | |||
| Male | 3 (42.9) | 28 (56.0) | 17 (56.7) | |
| Female | 4 (57.1) | 22 (44.0) | 13 (43.3) | |
| Tumor size (mm)a | < .001b | |||
| Mean ± SD | 17.2 ± 5.1 | 25.9 ± 9.2 | 35.3 ± 15.0 | |
| PTTG1 (%) | .013b | |||
| High | 0 | 11 (22.0) | 14 (46.7) | |
| Negative or low | 7 (100) | 39 (78.0) | 16 (53.3) | |
| PITX2 (%) | .745 | |||
| High | 3 (42.9) | 19 (38.0) | 14 (46.7) | |
| Low or negative | 4 (57.1) | 31 (62.0) | 16 (53.3) | |
| Galectin-3 (%) | .605 | |||
| High | 1 (14.3) | 15 (30.0) | 7 (23.3) | |
| Low or negative | 6 (85.7) | 35 (70.0) | 23 (76.7) | |
| E-cadherin (%) | .989 | |||
| Positive | 3 (42.9) | 23 (46.0) | 13 (43.3) | |
| Negative | 4 (57.1) | 27 (54.0) | 17 (56.7) | |
| Ki-67 index (%) | .681 | |||
| Mean ± SD | 1.5 ± 0.8 | 1.6 ± 2.0 | 1.2 ± 1.1 | |
Values are presented as number (%) unless otherwise indicated.
SD, standard deviation; PTTG1, pituitary tumor transforming gene 1; PITX2, paired-like homeodomain 2.
a
Unknown tumor size in two cases in group III;
b
Statistically significant (p < .05).