Fig. 2.

Each bar represents an individual subject. Purple (Zephyr valve) and blue (SoC) bars represent subjects that met or exceeded MCID for FEV₁(absolute change) of 100 mL and (percent change) of ≥12% improvement in FEV₁, SGQR (−4 points), and 6MWD (+26 m). The lighter colored bars represent subjects who did not meet the MCID. Dotted line represents the MCID. The open grey bars and grey “0” represent the subject with imputed data using the “Last Observation Carried Forward” method. SoC, standard of care; 6MWD, six-minute walk distance; MCID, minimal clinically important difference; SGRQ, St. George's Respiratory Questionnaire.