Table 3.
Logistic Regression Analysis for the 1,500 Combinations of Case-Participants
| All Variables | Only Baseline Variables | |||
|---|---|---|---|---|
| OR, 95% CI | p-value | OR, 95% CI | p-value | |
| Genotype | <0.0001 | <0.0001 | ||
| Pi*ZZ vs Pi*MZ | 13.97 (5.47, 35.62) | 15.06 (5.96, 38.05) | ||
| Pi*SZ vs Pi*MZ | 5.87 (2.95, 11.66) | 5.95 (3.05, 11.64) | ||
| AAT serum level (g/l) | 0.0090 | 0.0160 | ||
| 1 vs 5 (<0.25 vs =0.80) | 8.17 (2.59, 25.72) | 7.32 (2.36, 22.66) | ||
| 2 vs 5 (<0.50 vs =0.80) | 5.43 (2.01, 14.71) | 4.59 (1.72, 12.29) | ||
| 3 vs 5 (<0.57 vs =0.80) | 2.85 (1.19, 6.84) | 2.63 (1.12, 6.20) | ||
| 4 vs 5 (<0.80 vs =0.80) | 1.91 (0.98, 3.69) | 1.84 (0.95, 3.54) | ||
| Age (years) | <0.0001 | <0.0001 | ||
| 1 vs 5 (<30 vs =75) | 11.90 (6.82, 20.78) | 11.72 (6.79, 20.23) | ||
| 2 vs 5 (<45 vs =75) | 7.07 (4.21, 11.87) | 7.22 (4.35, 11.99) | ||
| 3 vs 5 (<60 vs =75) | 5.04 (3.13, 8.14) | 5.29 (3.31, 8.45) | ||
| 4 vs 5 (<75 vs =75) | 4.54 (2.71, 7.60) | 4.66 (2.81, 7.73) | ||
| FEV1 (%) | <0.0001 | <0.0001 | ||
| 1 vs 5 (<30 vs =75) | 2.56 (1.53, 4.30) | 2.72 (1.63, 4.54) | ||
| 2 vs 5 (<45 vs =75) | 2.98 (1.83, 4.86) | 2.98 (1.84, 4.81) | ||
| 3 vs 5 (<60 vs =75) | 3.87 (2.41, 6.21) | 4.09 (2.57, 6.50) | ||
| 4 vs 5 (<75 vs =75) | 2.66 (1.60, 4.41) | 2.89 (1.76, 4.73) | ||
| FEV1 - decline/year | 0.0303 | |||
| 1 vs 5 (>150 vs =30) | 2.04 (1.22, 3.43) | |||
| 2 vs 5 (>100 vs =30) | 1.74 (1.06, 2.86) | |||
| 3 vs 5 (>50 vs =30) | 1.74 (1.09, 2.75) | |||
| 4 vs 5 (>30 vs =30) | 1.26 (0.77, 2.05) | |||
| DLCO - decline/year | 0.0318 | |||
| 1 vs 5 (>20 vs =5) | 1.03 (0.62, 1.73) | |||
| 2 vs 5 (>15 vs =5) | 1.31 (0.82, 2.09) | |||
| 3 vs 5 (>10 vs =5) | 1.38 (0.90, 2.11) | |||
| 4 vs 5 (>5 vs =5) | 1.99 (1.24, 3.19) | |||
| Emphysema on CT scan | <0.0001 | <0.0001 | ||
| Mild vs Absent | 3.14 (1.94, 5.08) | 2.95 (1.83, 4.73) | ||
| Moderate vs Absent | 3.56 (2.29, 5.53) | 3.47 (2.25, 5.35) | ||
| Severe vs Absent | 5.38 (3.35, 8.63) | 5.37 (3.37, 8.55) | ||
| Very severe vs Absent | 5.42 (3.27, 8.98) | 5.22 (3.16, 8.61) | ||
Abbreviations: Pi, proteinase inhibitor; AAT, alpha-1 antitrypsin; g, grams; L, liter; FEV1, forced expiratory volume in one second; DLCO, diffusion capacity of the lung for carbon monoxide; CT, computed tomography; mMRC, modified Medical research Council; mL, milliliter; y, year.