Table 4.
Logistic Regression Analysis for the 1,500 Combinations of Case-Participants Divided by AAT Genotype
| Pi*ZZ (n= 450) | Pi*SZ (n=600) | Pi*MZ (n=450) | ||||
|---|---|---|---|---|---|---|
| OR, (95% CI) | p-value | OR, (95% CI) | p-value | OR, (95% CI) | p-value | |
| AAT serum level (g/l) | 0.087 | 0.065 | ||||
| 1 vs 2 (<0.25 vs <0.50) | 1.73 (0.92, 3.23) | 2.38 (1.14, 4.97) | ||||
| 2 vs 3 (<0.50 vs <0.57) | 1.42 (0.82, 2.46) | |||||
| Age (years) | <0.001 | <0.001 | <0.001 | |||
| <30 vs 75 or more | 16.25 (5.35, 49.35) | 10.94 (5.14, 23.27) | 34.45 (6.24, 190.18) | |||
| <45 vs 75 or more | 7.81 (2.97, 20.52) | 5.26 (2.57, 10.77) | 11.06 (2.23, 54.98) | |||
| <60 vs 75 or more | 7.74 (3.06, 19.55) | 5.45 (2.83, 10.49) | 2.70 (0.51, 14.26) | |||
| <75 vs 75 or more | 3.14 (1.20, 8.23) | 5.31 (2.65, 10.62) | 2.40 (0.44, 13.05) | |||
| FEV1 (%) | <0.001 | <0.001 | ||||
| <30 vs 75 or more | 1.43 (0.52, 3.91) | 3.59 (1.68, 7.68) | ||||
| <45 vs 75 or more | 5.04 (1.98, 12.81) | 3.19 (1.54, 6.64) | ||||
| <60 vs 75 or more | 5.48 (2.21, 13.55) | 5.28 (2.60, 10.70) | ||||
| <75 vs 75 or more | 2.13 (0.89, 5.11) | 4.38 (2.00, 9.61) | ||||
| FEV1 decline/year (mL) | <0.001 | |||||
| >150 vs 30 or less | 4.51 (1.11, 18.37) | |||||
| >100 vs 30 or less | 1.54 (0.50, 4.74) | |||||
| >50 vs 30 or less | 2.60 (0.95, 7.11) | |||||
| >30 vs 30 or less | 0.61 (0.22, 1.69) | |||||
| DLCO (%) | 0.007 | |||||
| <25 vs 70 or more | 0.29 (0.06, 1.44) | |||||
| <50 vs 70 or more | 3.61 (1.04, 12.52) | |||||
| <60 vs 70 or more | 2.43 (0.79, 7.53) | |||||
| <70 vs 70 or more | 0.51 (0.11, 2.37) | |||||
| DLCO(%) - decline/year | 0.009 | |||||
| >20 vs 5 or less | 0.25 (0.03, 1.77) | |||||
| >15 vs 5 or less | 0.62 (0.13, 2.96) | |||||
| >10 vs 5 or less | 2.39 (0.58, 9.80) | |||||
| >5 vs 5 or less | 2.35 (0.52, 10.55) | |||||
| Emphysema on CT scan | <0.001 | <0.001 | ||||
| Mild vs Absent | 8.73 (3.19, 23.83) | 2.34 (1.24, 4.41) | ||||
| Moderate vs Absent | 5.71 (2.30, 4.16) | 2.71 (1.52, 4.80) | ||||
| Severe vs Absent | 8.98 (3.53, 22.88) | 4.98 (2.69, 9.21) | ||||
| Very severe vs Absent | 8.16 (2.88, 23.12) | 6.34 (3.18, 12.63) | ||||
| Symptoms (mMRC) | 0.006 | |||||
| 1 vs 0 | 21.38 (2.44, 187.64) | |||||
| 2 vs 0 | 11.87 (1.43, 98.44) | |||||
| 3 vs 0 | 5.81 (0.64, 52.49) | |||||
| 4 vs 0 | 3.12 (0.28, 34.09) | |||||
Abbreviations: Pi, proteinase inhibitor; AAT, alpha-1 antitrypsin; g, grams; L, liter; FEV1, forced expiratory volume in one second; DLCO, diffusion capacity of the lung for carbon monoxide; CT, computed tomography; mMRC, modified Medical research Council; mL, milliliter.