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. 2022 Jan 10;8:18. doi: 10.1038/s41420-021-00785-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The survival rate of mice within 7 days (sham group: N = 10; other groups: N = 15). B The mRNA expressions of IL-6, TNF-α, and IL-1β in mouse lung tissue were detected using RT-qPCR 24 h after CLP induction, N = 8. C The protein contents of IL-6, TNF-α and IL-1β in mouse lung tissues were detected using ELISA. D The wet/dry ratio was used to calculate the formation of pulmonary edema, N = 8. E 24 h after CLP, Evans blue dye was injected to measure pulmonary vascular leakage, N = 8. F The morphological changes of lung were measured (scale bar = 25 μm) and the tissue injury was quantitatively analyzed (N = 8) using HE staining. Measurement data are depicted as mean ± SD. One-way ANOVA was employed for the comparisons among multiple groups, followed by Tukey’s multiple comparisons test. *p < 0.05 vs. CLP + PBS group; #p < 0.05 vs. CLP + Exo group. Kaplan-Meier method was used to calculate the survival rate. Log-rank test was used for univariate analysis.