Table 2.
Selection of the most represented biological categories and signaling pathways.
| Category | Pathway | P Value | Objects |
|---|---|---|---|
| Apoptosis and survival | HTR1A signaling | 2.7e-4 | 15/38 |
| IAP-proteins | 2.6e-2 | 9/29 | |
| BAD phosphorylation | 4.1e-2 | 10/36 | |
| Development | Leptin signaling via PI3K-dependent pathway | 6.0e-5 | 15/34 |
| A2A receptor signaling | 7.4e-3 | 12/37 | |
| IGF-a receptor signaling | 1.6e-3 | 15/44 | |
| GM-CSF signaling | 9.1e-3 | 14/47 | |
| Flt3 signaling | 1.8e-2 | 12/41 | |
| Cytoskeleton remodeling | Role of PKA in cytoskeleton reorganization | 4.8e-3 | 11/31 |
| Cytoskeleton remodeling, TGF,WNT and cytoskeletal remodeling | 1.2e-3 | 29/107 | |
| Integrin outside-in signaling | 7.7e-5 | 18/46 | |
| Cell adhesion | Integrin-mediated cell adhesion and migration | 2.0e-4 | 17/45 |
| Signal transduction | IP3 signaling | 5.7e-7 | 19/38 |
| cAMP signaling | 1.0e-2 | 11/34 | |
| Erk interactions | 1.5e-2 | 10/31 | |
| Regulation of lipid metabolism | Regulation of acetyl-CoA carboxylase 1 activity in keratinocytes, | 8.0e-5 | 6/7 |
| Regulation of acetyl-CoA carboxylase 1 activity in lipogenic tissues | 8.0e-5 | 6/7 | |
| Transcription | ChREBP regulation pathway | 8.5e-3 | 6/13 |
| Immune response | CD28 | 1.0e-4 | 17/43 |
| NFAT in immune response | 1.8e-5 | 18/42 | |
| BCR pathway | 9.5e-4 | 15/42 | |
| T cell receptor signaling | 2.1e-3 | 15/45 | |
| ICOS pathway in T-helper cell | 7.2e-4 | 14/37 | |
| NF-AT signaling and leukocyte interactions | 3.2e-3 | 13/38 | |
| CCR5 signaling in macrophages and T lymphocytes | 1.3e-2 | 13/44 |
Genes that showed differentially expressed between cisplatin-sensitive and –resistant EC cells were analyzed for biological pathway representation using GeneGo MetaCore software (P <0.002). IPS, inositol triphosphate.