TABLE 2.

Summary of studies examining steady-state gene and protein expression of circadian genes of interest in various animal models of epilepsy

Gene of interest	Study reference	Animal model of epilepsy	Brain region examined	mRNA level	Protein level
Clock	Matos et al. 201825	Rat pilocarpine model	Hippocampus	Reduced	Not examined
	Kim et al. 201826	Rat acute ECS model	Frontal cortex	Unaffected	Reduced
	Wallace et al. 201827	Kcna1-null mice	Anterior hypothalamus	Not examined	Unaffected
Bmal1	Matos et al. 201825	Rat pilocarpine model	Hippocampus	Reduced	Not examined
	Kim et al. 201826	Rat acute ECS model	Frontal cortex	Reduced	Reduced
	Wallace et al. 201827	Kcna1-null mice	Anterior hypothalamus	Not examined	Unaffected
Per1	Matos et al. 201825	Rat pilocarpine model	Hippocampus	Increased acutely; returned to wild-type level on chronic phase	Not examined
	Kim et al. 201826	Rat acute ECS model	Frontal cortex	Reduced	Reduced
	Wallace et al. 201827	Kcna1-null mice	Anterior hypothalamus	Not examined	Unaffected
	Eun et al. 201132	Mouse acute kainic acid or ECS treatment	Hippocampus and neocortex	Increased acutely and then returned to wild-type level	Increased acutely
Rev-erbα	Kim et al. 201826	Rat acute ECS model	Frontal cortex	Increased	Increased
	Yue et al. 202036	Mouse pilocarpine model	Hippocampus and temporal neocortex	Not examined	Reduced
Rorα	Kim et al. 201826	Rat acute ECS model	Frontal cortex	Reduced	Reduced
Dbp	Klugmann et al. 200634	Rat kainic acid model	Hippocampus	Reduced	Not examined

Abbreviations: ECS, electroconvulsive seizure.