Table 1.

Demographics and clinical characteristics

	All patients 56 women 61 pregnancies 202 visits	Subgroup for PK model 22 women 22 pregnancies 55 visits
	N (%) or median (IQR)	N (%) or median (IQR)
Age (years)	31 (27.5–34.3)	32 (28.9–34.6)
Race
White	29 (47.5%)	9 (40.9%)
Black	30 (49.2%)	12 (54.5%)
Other	2 (3.3%)	1 (4.5%)
Weight (kg), visit*	79.4 (66.7–96.3)	81.1 (65.7–100)
Missing weight, visit	5 (2.5%)	2 (3.6%)
Active LN in last 3 years	9 (14.8%)	2 (9.1%)
Serum creatinine (mg/dL), visit*	0.6 (0.5–0.8)	0.7 (0.6–0.8)
Missing serum creatinine, visit*	24 (11.9%)	7 (12.7%)
Disease activity (PGA)	0.33 (0–0.75)	0.25 (0.05–0.67)
Disease activity (PGA), visit*	0.39 (0–0.63)	0.18 (0–0.62)
Prednisone use, visit*	68 (33.7%)	14 (25.5%)
Prednisone dosage (mg), visit*	10 (5–20)	7.5 (5–13.4)
Azathioprine use, visit*	74 (36.6%)	17 (30.9%)
HCQ daily dosage (mg), visit*
400	157 (77.7%)	41 (74.5%)
200	18 (8.9%)	5 (9.1%)
Other	27 (13.4%)	9 (16.4%)
HCQ dosing interval (hour), visit*
24	141 (69.8%)	39 (70.9%)
12	61 (30.2%)	16 (29.1%)

*'Visit’ represents the value across all study visits; whereas the data otherwise represent values averaged across all time points for each unique pregnancy. Weight and creatinine represent observed value before imputing missing data.

HCQ, hydroxychloroquine; LN, lupus nephritis; PGA, Physician Global Assessment; PK, pharmacokinetic.