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. 2022 Jan 7;9(1):e000602. doi: 10.1136/lupus-2021-000602

Table 2.

Predicted HCQ pharmacokinetics throughout pregnancy and post partum*

Trimester Half-life (days) Apparent clearance (L/hour) Apparent volume of distribution (L)
First 21.4 (16.1) 42.1 (15.3) 27 589 (17 248)
Second 24.1 (16.7) 48.8 (17.6) 35 935 (19 645)
Third 22.1 (12.7) 53.0 (18.9) 36 201 (15 627)
Post partum 32.4 (20.2) 33.2 (11.8) 33 164 (16 478)

*Data presented as mean (SD) of the empirical Bayesian estimates.

HCQ, hydroxychloroquine.