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. 2022 Jan 10;19:13. doi: 10.1186/s12974-022-02378-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A Hematoxylin and eosin-stained sections, showing the OE thickness in the right nasal septum of the Control day 3, Poly(I:C) day 3, Control day 9, Poly(I:C) day 9, Control day 21, and Poly(I:C) day 21 groups (Scale bar = 50 μm). B Comparison of the OE thicknesses in the nasal septum, tegmen, and lateral area, respectively, at day 3, day 9, and day 21 among the groups. C Immunostained sections, showing mature OSNs in the right nasal septum of the Control day 3, Poly(I:C) day 3, Control day 9, Poly(I:C) day 9, Control day 21, and Poly(I:C) day 21 groups (Scale bar = 50 μm). D Comparison of the number of mature OSNs in the three-described areas at day 3, day 9, and day 21 among the studied groups. E Comparison of the latency [sec] to find the buried food at day 3, day 9, and day 21 between the Control and Poly(I:C) groups. Statistical analysis was performed using the Mann–Whitney U test, with P < 0.05 (*) and P < 0.01 (**) representing statistical significance. The error bars represent the standard error of the mean (n = 5). OE olfactory epithelium, OSNs olfactory sensory neurons, Poly(I:C) polyinosinic–polycytidylic acid