Table 1.

Summary of Findings

Disease Model	How comprehensive is the body of sleep/circadian research in this model?	Does this model reflect human PD-related circadian rhythm changes?	Does this model reflect human PD-related sleep dysfunction?	References
6-OHDA	***	++	+++	[18–36]
MPTP	***	--	---	[37–46]
Rotenone	**	+	+	[47–53]
α-Synuclein Transgenic	**	++	+++	[54–59]
LRRK-G2019S Transgenic	*	N/A	+	[60]
VMAT2-deficient	*	-	--	[61, 62]
MitoPark	*	+++	+++	[63, 64]
Cycad	*	+	N/A	[65]
Paraquat/Maneb	N/A	N/A	N/A	––––
PFF	N/A	N/A	N/A	––––
Other Transgenic models (i.e. DJ-1, PINK)	N/A	N/A	N/A	––––

Table 1: Evidence is indicated by – and +, with --- being compelling evidence for a lack of a PD-like phenotype, +++ being compelling evidence of a PD-like phenotype, comprehensiveness of the body of research indicated by asterisks, where *** is very comprehensive, ** requires further studies to corroborate and further confirm, * a very limited number of studies have been relied upon to arrive at the particular conclusion, N/A where no studies have been performed