Table 1.
Baseline ambulance and hospital admission characteristics of Mimic patients enrolled in the RIGHT-2 trial. Data are number (%), median [IQR], or mean (standard deviation)
| All | GTN | Sham | Difference | 2p | |
|---|---|---|---|---|---|
| Ambulance data (pre-randomisation) | |||||
| Number of patients | 297 | 134 | 163 | ||
| Age (years) | 67 (18) | 68 (19) | 66 (18) | 1.7 (− 2.4, 5.9) | 0.41 |
| < 60 (%) | 107 (36) | 49 (37) | 58 (36) | ||
| 60–70 (%) | 45 (15) | 17 (13) | 28 (17) | ||
| 70–80 (%) | 55 (19) | 22 (16) | 33 (20) | ||
| ≥ 80 (%) | 90 (30) | 46 (34) | 44 (27) | ||
| Sex (female) (%) | 157 (53) | 74 (55) | 83 (51) | 4.3 (−7.1, 15.7) | 0.46 |
| Time from onset to randomisation (minutes) | 75 [47,126] | 72.5 [48,120] | 79 [46,140] | −6.0 (−19.0, 5.0) | 0.27 |
| ECG, AF/flutter (%) | 29 (13) | 11 (11) | 18 (15) | 3.6 (−5.1, 12.3) | 0.42 |
| Systolic blood pressure (mmHg) | 159 (26) | 155 (24) | 162 (27) | −7.0 (−12.9, − 1.1) | 0.021 |
| Diastolic blood pressure (mmHg) | 91 (16) | 89 (16) | 92 (16) | −2.7 (−6.4, 1.0) | 0.15 |
| Heart rate (bpm) | 83 (19) | 82 (16) | 84 (21) | −1.7 (−5.9, 2.6) | 0.44 |
| Glasgow coma scale | 14 (2) | 14 (2) | 14 (2) | −0.3 (−0.7, 0.1) | 0.13 |
| Glasgow coma scale < 14 (%) | 73 (25) | 39 (29) | 34 (21) | −8.2 (−18.2, 1.8) | 0.11 |
| FAST score (/3) | 2 (1) | 2 (1) | 2 (1) | 0.0 (−0.1, 0.2) | 0.61 |
| FAST score = 3 (%) | 144 (49) | 67 (50) | 77 (48) | −2.9 (−14.3, 8.6) | 0.63 |
| Hospital admission data (post randomisation) | |||||
| Number of patients with data | 297 | 134 | 163 | ||
| Ethnic group, non-white (%) | 35 (13) | 15 (12) | 20 (13) | 1.2 (−6.7, 9.0) | 0.77 |
| Ethnicity, White (%) | 242 (87) | 110 (88) | 132 (87) | ||
| Ethnicity, Black (%) | 14 (5) | 5 (4) | 9 (6) | ||
| Ethnicity, Asian (%) | 18 (6) | 10 (8) | 8 (5) | ||
| Ethnicity, Other (%) | 3 (1) | 0 (0) | 3 (2) | ||
| Pre-morbid mRS [/5] | 1 [0,3] | 1 [0,3] | 0 [0,3] | 0.00 (0.00, 0.00) | 0.21 |
| Pre-morbid mRS > 2 (%) | 79 (28) | 39 (31) | 40 (26) | −4.7 (−15.3, 5.9) | 0.38 |
| Medical history (%) | |||||
| Hypertension | 142 (51) | 61 (49) | 81 (53) | 4.1 (−7.8, 15.9) | 0.50 |
| Diabetes mellitus | 59 (21) | 27 (22) | 32 (21) | −0.6 (−10.3, 9.2) | 0.91 |
| Previous stroke | 85 (31) | 37 (30) | 48 (32) | 2.2 (−8.7, 13.1) | 0.70 |
| Ischaemic heart disease | 58 (21) | 29 (24) | 29 (19) | −4.2 (−14.1, 5.6) | 0.39 |
| Smoking, current | 54 (24) | 26 (25) | 28 (23) | −2.2 (−13.4, 8.9) | 0.69 |
| Antiplatelets | 69 (36) | 36 (40) | 33 (33) | −7.0 (−20.7, 6.7) | 0.32 |
| Anticoagulants | 33 (17) | 15 (17) | 18 (18) | 1.0 (−9.7, 11.7) | 0.86 |
| Either | 96 (51) | 47 (52) | 49 (49) | −3.2 (−17.5, 11.0) | 0.66 |
| OCSP syndrome, TACS (%) | 40 (18) | 15 (16) | 25 (19) | 3.6 (−6.4, 13.6) | 0.49 |
| NIHSS (/42) | 4 [2,8] | 4 [1,9] | 4 [2,7] | 0.0 (−1.0, 1.0) | 0.64 |
AF atrial fibrillation, bpm beats per minute, ECG electrocardiogram, FAST face-arm-speech test, GTN glyceryl trinitrate, IQR interquartile range, mmHg millimetres of mercury, mRS modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale, OCSP Oxford Community Stroke Project classification, TACS total anterior circulation stroke. The pre-morbid mRS, as reported by patient or representative, is the functional status of the participant prior to the onset of suspected stroke symptoms