Table 1.
Clinical characteristics among intracerebral hemorrhage patients grouped by baseline estimated glomerular filtration rate
| Variables | eGFR at baseline (ml/min/1.73 m2) | |||||
|---|---|---|---|---|---|---|
| Total (N = 85,167) |
≥90 (N = 58,418) |
60–89 (N = 17,256) |
45–59 (N = 3507) |
< 45 (N = 5986) |
P Value | |
| Demographic | ||||||
| Age, y, mean (SD) | 62.9 ± 12.9 | 60.8 ± 12.1 | 68.3 ± 12.9 | 69.5 ± 13.4 | 63.8 ± 13.9 | <.0001 |
| Male, n (%) | 53,208 (62.5) | 36,846 (63.1) | 10,680 (61.9) | 2060 (58.7) | 3622 (60.5) | <.0001 |
| Physical examination, mean (SD) | ||||||
| BMI, kg/m2 | 23.9 ± 4.5 | 23.9 ± 4.1 | 23.6 ± 4.3 | 23.6 ± 3.9 | 24.3 ± 8.2 | <.0001 |
| SBP, mmHg | 164.6 ± 28.2 | 163.3 ± 27.34 | 166.3 ± 28.9 | 169.0 ± 30.1 | 168.7 ± 32. | <.0001 |
| DBP, mmHg | 95.3 ± 16.9 | 95.2 ± 16.4 | 94.8 ± 17.4 | 95.7 ± 18.2 | 97.1 ± 19.3 | <.0001 |
| Medical history, n (%) | ||||||
| Prior stroke or TIA | 24,472 (28.7) | 16,177 (27.7) | 5096 (29.5) | 1128 (32.2) | 2071 (34.6) | <.0001 |
| Prior CHD or myocardial infarction | 4779 (5.6) | 2945 (5.0) | 1136 (6.6) | 293 (8.4) | 405 (6.8) | <.0001 |
| Hypertension | 61,488 (72.2) | 41,188 (70.5) | 12,892 (74.7) | 2706 (77.2) | 4702 (78.5) | <.0001 |
| Dyslipidemia | 7246 (8.5) | 4636 (7.9) | 1613 (9.3) | 370 (10.6) | 627 (10.5) | <.0001 |
| Atrial fibrillation | 1304 (1.5) | 644 (1.1) | 425 (2.5) | 111 (3.2) | 124 (2.1) | <.0001 |
| Diabetes mellitus | 8335 (9.8) | 5182 (8.9) | 1731 (10.0) | 446 (12.7) | 976 (16.3) | <.0001 |
| PVD | 822 (1.0) | 465 (0.8) | 205 (1.2) | 46 (1.3) | 106 (1.8) | <.0001 |
| Behavioral history, n (%) | ||||||
| Current smoking | 16,767 (19.7) | 12,179 (20.8) | 3080 (17.8) | 556 (15.9) | 952 (15.9) | <.0001 |
| Drinking | 20,790 (24.4) | 14,795 (25.3) | 3812 (22.1) | 705 (20.1) | 1478 (24.7) | <.0001 |
| Laboratory test, median (IQR) | ||||||
| LDL cholesterol, mmol/L | 2.6 (2.0–3.2) | 2.6 (2.0–3.2) | 2.6 (2.1–3.2) | 2.7 (2.1–3.4) | 2.8 (1.9–4.3) | <.0001 |
| GHb, mmol/L | 139.0 (125.0–153.0) | 141.0 (128.0–154.0) | 134.0 (121.0–149.0) | 130.0 (120.0–143.0) | 120.0 (100.0–143.0) | <.0001 |
| Hcy, mmol/L | 13.7 (10.0–20.0) | 13.0 (9.5–19.0) | 14.6 (10.5–20.6) | 16.0 (11.3–23.1) | 18.9 (10.5–31.5) | <.0001 |
| Creatinine, μmmol/L | 67.7 (55.0–85.0) | 60.0 (50.1–70.0) | 88.0 (77.0–98.8) | 118.3 (101.6–131.0) | 231.0 (159.0–440.0) | <.0001 |
| BUN, mmol/L | 5.1 (4.0–6.6) | 4.8 (3.8–6.0) | 5.8 (4.7–7.2) | 7.1 (5.7–9.0) | 9.1 (5.3–13.1) | <.0001 |
| eGFR, ml/min/1.73 m2 | 101.4 (84.0–113.6) | 108.8 (100.5–118.3) | 78.6 (70.9–85.0) | 53.9 (49.9–57.2) | 23.4 (10.4–35.0) | <.0001 |
| Uric acid, μmmol/L | 277.0 (210.0–354.0) | 260.0 (200.4–329.0) | 311.0 (240.7–382.5) | 347.0 (263.0–432.0) | 352.0 (216.0–483.0) | <.0001 |
SD standard deviation; BMI body mass index; SBP systolic blood pressure; DBP diastolic blood pressure; TIA transient ischemic attack; CHD chronic heart disesea; PVD peripheral vascular disorder; LDL low-density lipoprotein; GHb glycated hemoglobin; Hcy homocysteine; BUN blood urea nitrogen; eGFR estimated glomerular filtration rate