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. 2022 Jan 10;20:30. doi: 10.1186/s12951-021-01213-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Characterization of tumor spheroids generation in the 3DHSP. A Schematic describing spheroid generation in the 3DHSP. B Optical images of BT474, SKOV3, and U87 spheroids in the 3DHSP for 1 and 2 d. Scale bar: 200 μm. C Size of the spheroids after 1 and 2 d. D Representative fluorescent images of three kinds of tumor spheroids for 2 d, showing the live (green) and dead (red) cells. E Fluorescence intensity of live/dead cells in three types of tumor spheroids for 2 d (n ≥ 10). Student’s t-test: **p < 0.01, ***p < 0.001. Scale bar: 200 μm