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. 2022 Jan 10;20:32. doi: 10.1186/s12951-021-01229-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Detection of the titre of neutralizing antibody induced by self-assembled immunogen and the immune effect on lymphocytes. A The neutralization titre of the antibody was detected by the microneutralization method. Under the condition of the 100TCID₅₀ CDV-11 strain, the half inhibitory dose of neutralizing antibody (ID₅₀) was calculated. B Ferritin, YaH₃F, YaH₄F, YaH5F, combined immunization, PBS and YaHF induced lymphocyte proliferation stimulated by peptides, haemagglutinin, ConA and LPS. C Representative flow cytometric plots for measuring recruited and/or activated CD3/CD4 and CD3/CD8 in mice vaccinated with ferritin, YaH₃F, YaH₄F, YaH5F, combined immunization, PBS and YaHF. D Percentage of recruited and/or activated CD3 cells to lymphocytes. Differentiation degrees of CD4 from CD3 E and CD8 from CD3 F are shown. G The killing efficiency of antibody-dependent cell-mediated cytotoxicity (ADCC) compared with Triton X-100. Comb stands for combined immunization. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001