Table 1.
Association of OPRM1 methylation in peripheral blood leukocyte DNA and breast cancer risk.
| Methylation statusa | Cases no. (%) | Controls no. (%) | ORcrude | ORadj |
|---|---|---|---|---|
| (95%CI) | (95%CI) | |||
| Hypomethylation | 79 (19.7) | 160 (34.0) | 1.000 | 1.000 |
| Hypermethylation | 322 (80.3) | 310 (66.0) | 2.104 (1.541–2.872)b | 1.914 (1.357–2.777)b |
ORcrude, odds ratio generated by univariate logistic regression; ORadj, odds ratio adjusted by marital status, education level, occupation, and family history of cancer.
a
Methylation status, the methylation cut-off value (0.0076) was selected according to the maximum Yoden index.
b
P < 0.0001.