Figure 2.

Ex4’s single treatment fails to potentiate the non-confined extinction of cocaine-induced CPP. (A) The experimental schedule for non-confined extinction procedures and saline (sal), cocaine (Coc), as well as exendin4 (Ex4) treatment protocols. (B) CPP scores of pre-test and post-test indicate that most animals showed a significant place preference following cocaine-paired CPP training. N = 12 per group, **represents p < 0.01 vs. pretest, paired t-test. (C) CPP scores of vehicle or Ex4 suggest that after four non-confined extinction sessions single treatment with Ex4 on the test day failed to induce a significant reduction in cocaine-induced CPP scores compared to vehicle. N = 6 per group, ns represents no significance, Student’s t-test. Data are expressed as mean ± SEM.