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. 2021 Nov 24;15:711750. doi: 10.3389/fnsys.2021.711750

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Copyright © 2021 Zhu, Hong, Li, Jiang, Guo, Wang, Ding, Gao, Sun, Sun, Wang, Wang and Wan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ex4’s treatment 0 h after extinction session drives the confined of cocaine-induced CPP. (A) The experimental schedule for confined extinction procedures and saline (Sal), cocaine (Coc), as well as extendin4 (Ex4) treatment protocols. (B) CPP scores of pre-test and post-test indicate that most animals showed a significant place preference following cocaine-paired CPP training. N = 12 per group, **represents p < 0.01 vs. pretest, paired t-test. (C) CPP scores of vehicle or Ex4 suggest that after four confined extinction sessions treatment with Ex4 0 h after each extinction session induced a significant reduction in cocaine-induced CPP scores compared to vehicle. N = 6 per group, ^##represents p < 0.01, Student’s t-test. Data are expressed as mean ± SEM.