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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Virol. 2020 Dec 17;47:1–8. doi: 10.1016/j.coviro.2020.11.002

Figure 2: Viruses disrupt NMD and SMD.

Figure 2:

Both cis-acting RNA sequences and trans-acting viral proteins interfere with NMD. Flavivirus-mediated inhibition of NMD generally involves interfering with EJC components. SMD is disrupted by IAV NS1 blocking Upf1 association with Stau1.