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. 2021 Dec 21;23(1):47. doi: 10.3390/ijms23010047

Figure 2.

Figure 2

Myeloid ABCG1 deficiency promotes MWCNT-induced apoptosis in BAL cells. (A) MWCNT instillation increases oxidative stress in BAL cells of C57BL/6J and ABCG1 KO. Cytospins of BAL cells from C57BL/6J and ABCG1 KO mice either sham or MWCNT instilled were stained with CellRox green and nuclear stain, DAPI (blue). Scale bars: 50 μm. (B) Mean Fluorescence intensity was measured in 18 random fields per one cytospin for each mouse using Zen software (blue edition). (C) Measurement of Caspase 3/7 activity in BAL cells using Caspase-Glo 3/7 Assay and quantification of relative luminescence in 104 cells. (* p ≤ 0.05, N ≥ 3).