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. 2021 Dec 21;23(1):37. doi: 10.3390/ijms23010037

Figure 6.

Figure 6

Schematic diagram showing that IL-2(Rapa+)/T with weak mTORC1/S6K (weak yang) but strong AMPK (yin) signaling become T-cell memory via activation of the (yin) FOXO1-TCF1-Eomes transcriptional pathway and the (yin) AMPK-ULK1-ATG7 metabolic axis, whereas IL-2/T-cells with strong mTOC1/S6K1 (yang) signaling differentiate into effector T-cells via activation of the (yang) T-bet transcriptional and the (yang) HIF-1α metabolic pathways. In the figure, red color part represents yang controlling cell growth, differentiation and functional effect, and using glycolysis for cell metabolic energy while blue color part represents yin regulating cell quiescence, and using FAO for cell metabolic energy.