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. 2022 Jan;32(1):111–123. doi: 10.1101/gr.275750.121

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© 2022 Sarkar et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 5. — Effect of depleting PIC components on Mediator association with gene promoters. (A) Heat maps and line graphs showing normalized occupancy of Med15 (tail) and Med18 (head) at TATA-containing, Taf1-depleted promoters from the 1000 genes with highest Pol II occupancy (228 genes); TATA-less, Taf1-enriched genes excluding RP genes from the 1000 genes with highest Pol II occupancy (330 genes); and RP genes after depletion of Kin28 alone or together with Taf1, TBP, or Rpb3, as indicated. (B) Heat maps and line graphs showing normalized occupancy of Med15 (tail) and Med18 (head) at the approximately 300 genes with highest Pol II occupancy after heat shock, Hsf1 targets, and RP genes after depletion of Kin28 alone or together with Taf1, TBP, or Rpb3, as indicated, without or with 15 min of heat shock, as indicated.