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. 2021 Dec 21;23(1):5. doi: 10.3390/ijms23010005

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cloverleaf model of human tRNA[Ser]^Sec. The image shows the 90 bases in human tRNA[Ser]^Sec. The paired 5′ and 3′ terminal bases constitute the acceptor stem, and on the left portion of the tRNA, the D stem and loop constitute six paired and four unpaired bases. On the lower portion of the tRNA, the anticodon stem and loop constitute six paired and seven unpaired bases, and the variable stem and loop constitute five paired and four unpaired bases. On the right portion of the tRNA, the TΨC stem and loop constitute four paired and seven unpaired bases. Human tRNA[Ser]^Sec contains base modifications at the following positions: 34 (mcm⁵U), 37 (i⁶A), 55 (Ψ), and 58 (m¹A). The two isoforms differ from one another at position 34 by a single methyl group on the 2′-O-ribosyl moiety.