Table 5.
Adjusted risk for non-survivors and survivors among SARS-CoV-2-positive veterans by indicated factors and comparisons.
| Stratum | Non- | Survivors ^ | aRR | Non | Survivors ^ | aRR | Effect (+|−) |
 Stratum |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| (Col/Row) | Survivors ^ | n (%) | (95%CI) † | Survivors ^ | n (%) | (95%CI) † | ΔaRR% ♦ | PInt †,¥ | PΔV †, ⅄ | ||
| n (%) | n (%) | MC’ ‡ | MC ‡ | MC’ ‡ | MC ‡ | ||||||
| Post Index → | Vitamin D (Yes versus No) | ||||||||||
| ↓ | Hospitalized + | Hospitalized − | |||||||||
| Corticosteroid + | 15 (3) | 149 (5) | 0.51 (0.29–0.88) | 6 (8) | 113 (5) | 2.5 (0.90–7.1) | −400 | 0.0071 | 0.028 | 0.057 | 0.12 |
| Corticosteroid − | 11 (2) | 181 (5) | 0.47 (0.26–0.84) | 11 (3) | 533 (3) | 0.51 (0.25–1.03) | −8 | 0.88 | 0.88 | ||
| Effect (+|−) | ΔaRR% ♦ | 8 | 400 | ||||||||
| PInt †,¥ | MC’ ‡ | 0.86 | 0.012 | ||||||||
| MC ‡ | 1 | 0.036 | |||||||||
Stratum
|
PΔH †,⅄ | MC’ ‡ | 0.062 | ||||||||
| MC ‡ | 0.062 | ||||||||||
| Post Index → | Corticosteroid (Yes versus No) | ||||||||||
| ↓ | Hospitalized + | Hospitalized − | |||||||||
| Vitamin D + | 15 (58) | 149 (45) | 3.0 (0.51–18) | 6 (35) | 113 (17) | 6.2 (0.72–53) | −103 | 0.62 | 0.62 | 0.81 | 0.81 |
| Vitamin D - | 534 (49) | 2615 (41) | 1.5 (1.3–1.7) | 69 (14) | 2137 (12) | 1.1 (0.81–1.4) | 43 | 0.018 | 0.071 | ||
| Effect (+|−) | ΔaRR% ♦ | 98 | 479 | ||||||||
| P Int †,¥ | MC’ ‡ | 0.45 | 0.11 | ||||||||
| MC ‡ | 0.91 | 0.34 | |||||||||
|
Stratum
|
PΔH †,⅄ | MC’ | 0.53 | ||||||||
| MC ‡ | 1.0 | ||||||||||
^ Non-referent group of the indicated comparison factor. † Adjusted for Age (≤60, 61–70, 71–80, >80), Alcohol Use Disorder (Yes, No), BMI (<18.5, 18.5–24.9, 25–29.9, ≥30), Charlson Comorbidity Index (0, 1–2, 3–4, 5+), Current Smoker (Yes, No), Location (Pacific-Mountain, Mid-West/Continental, East Coast), Race (White, Black, Other Race), Sex (Male, Female), and Time (March, April–September). ♦ Percentage change in aRR for hospitalized (+) versus non-hospitalized patients (−) on logarithmic scale. ¥ Unrestricted test for interaction on the additive scale. ‡ Uncorrected (MC’) | Corrected (MC) for multiplicity over 4 indicated strata within drug comparison using the Hochberg step-up procedure. ⅄ p-value for absolute difference (vertical/horizontal stratum effects, respectively). aRR = Adjusted relative risk; CI = confidence interval.