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. 2021 Dec 22;23(1):62. doi: 10.3390/ijms23010062

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Increase in thermogenic and beiging gene markers by apoCIII reduction improves catecholamine-induced lipolysis in VAT. (a–h) Expression of (a) UCP-1, (b) PGC1α, (c) PRDM16, (d) CIDEA, (e) CD137, (d) TMEM26 and (d) TBX1 mRNA in the prevention (filled bars) and reversibility (empty bars) studies. (i,j) Concentration–response curves of isoproterenol-induced lipolysis in isolated adipocytes from VAT from (i) the prevention and (j) reversibility studies. Data expressed as mean ± SEM of n = 4–5 individual mice per experimental group and controls. * p < 0.05; ** p < 0.01; *** p < 0.001 for differences in the prevention study. # p < 0.05; ## p < 0.001; ### p < 0.001 for differences in the reversibility study.