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. 2021 Dec 21;23(1):45. doi: 10.3390/ijms23010045

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of meldonium treatment (200 mg/kg for 4 weeks) on mitochondrial function/reactive oxygen species (ROS) production after in vitro anoxia-reoxygenation in left ventricular (LV) cardiac fibers in a model of pulmonary hypertension-induced right ventricle heart failure. Anoxia-reoxygenation induced a significantly higher H₂O₂ production rate and H₂O₂/O ratio in the monocrotaline (MCT) group than in the control group. Treatment with meldonium decreased anoxia-reoxygenation-induced H₂O₂ production to the level of the control group. The data are shown as the mean±SEM of 9 to12 experiments. * p < 0.05 vs. MCT group, one-way ANOVA with Dunnett’s multiple comparisons test.