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Effects of meldonium pretreatment on the lipopolysaccharide (LPS)-induced decrease in (A) ejection fraction and (B) fractional shortening. Pretreatment with meldonium significantly attenuated the development of the inflammation-induced decrease in the ejection fraction and fractional shortening of the left ventricle. The results are shown as the mean±SEM of 7 to 8 animals. * p < 0.05 vs. the LPS group, one-way ANOVA followed by Dunnett’s multiple comparison test.
