Table 1.

Effects of meldonium administration on right ventricular (RV) systolic pressure, right ventricle-to-body, left ventricle-to-body mass indexes and Fulton index. Treatment with meldonium significantly attenuated the development of RV hypertrophy and had no effect on RV systolic pressure.

	Control	MCT	MCT + Meldonium
RV systolic pressure, mmHg	19 ± 1 *	52 ± 5	41 ± 4
Right ventricle-to-body mass index, mg/g	0.50 ± 0.01 *	1.13 ± 0.06	0.88 ± 0.08 *
Fulton index, g/g	0.27 ± 0.01 *	0.53 ± 0.03	0.43 ± 0.04 *
Left ventricle-to-body mass index, mg/g	1.8 ± 0.1	2.0 ± 0.1	2.0 ± 0.1

The results are shown as the mean±SEM of 10 to 12 animals. * p < 0.05 vs. the monocrotaline (MCT) group, one-way ANOVA with Dunnett’s multiple comparison test.